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IMPORTANT SAFETY INFORMATION: INCIVEK combination treatment may cause serious side effects, including skin rash and serious skin reactions. Sometimes these skin rashes and other skin reactions can become serious, require treatment in a hospital, and it may lead to death. Call your healthcare provider right away if you develop any skin changes or itching during treatment with INCIVEK.

PLEASE SEE ADDITIONAL IMPORTANT SAFETY INFORMATION

For adults with chronic hepatitis C (genotype 1) infection with stable liver problems

Frequently Asked Questions

What is INCIVEK Triple Therapy?

INCIVEK® (telaprevir) is a prescription medicine used with the medicines peginterferon alfa and ribavirin to treat chronic (lasting a long time) hepatitis C genotype 1 infection in adults with stable liver problems, who have not been treated before, or who have failed previous treatment. It is not approved for any other genotype. Ask your healthcare provider what genotype you have.

It is not known if INCIVEK is safe and effective in children under 18 years of age.

Who should not take INCIVEK?

Do not take INCIVEK if you are pregnant or may become pregnant, or if you are a man with a sexual partner who is pregnant.

Do not take INCIVEK if you are taking certain medicines, as there could be serious side effects. If these drugs are taken together, this can cause you to have too much or not enough INCIVEK or your other medicines in your body. It can also cause side effects that can be serious or life threatening. These medicines include:

  • Alfuzosin hydrochloride (Uroxatral®)
  • Carbamazepine (Carbatrol®, Equetro®, Tegretol®)
  • Cisapride (Propulsid®)
  • Ergot-containing medicines, including:

    • Dihydroergotamine mesylate (D.H.E. 45®, Migranal®)
    • Ergotamine tartrate (Cafergot®, Migergot®, Ergomar®, Ergostat, Medihaler Ergotamine, Wigraine, Wigrettes)
    • Methylergonovine maleate (Ergotrate®, Methergine®)
  • Lovastatin (Advicor®, Altoprev®, Mevacor®)
  • Midazolam when taken by mouth
  • Phenobarbital
  • Phenytoin (Dilantin®, Phenytek®)
  • Pimozide (Orap®)
  • Rifampin (Rifadin®, Rifamate®, Rifater®)
  • Sildenafil citrate (Revatio®) or tadalafil (Adcirca®) for the lung problem pulmonary artery hypertension (PAH)
  • Simvastatin (Zocor®, Vytorin®, Simcor®)
  • St. John's wort (Hypericum perforatum) or products containing St. John's wort
  • Triazolam (Halcion®)

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. INCIVEK and other medicines can affect each other. Your healthcare provider may need to change the amount of medicines you take.

What are the side effects of INCIVEK Triple Therapy?

INCIVEK Triple Therapy may cause serious side effects, including:

Skin rash and serious skin reactions

  • Skin rash and serious skin reactions. Skin rashes are common with INCIVEK Triple Therapy. Sometimes these skin rashes and other skin reactions can become serious, require treatment in a hospital, and may lead to death
  • Call your healthcare provider right away if you develop any skin changes or itching during treatment with INCIVEK. Your healthcare provider will decide if your skin changes or any of the following symptoms may be a sign of a serious skin reaction:
    • Skin rash with or without itching, fever, swelling of your face, blisters or skin lesions, mouth sores or ulcers, or red or inflamed eyes, like "pink eye" (conjunctivitis)
  • Your healthcare provider will decide if you need treatment for your skin rash or if you need to stop taking INCIVEK or any of your other medicines
  • Never stop taking INCIVEK Triple Therapy without talking with your healthcare provider first

Anemia

  • Low red blood cell count (anemia) that can be severe. Tell your healthcare provider if you have any of these symptoms of anemia:
    • Dizziness, shortness of breath, tiredness, or weakness
  • Your healthcare provider will do blood tests regularly to check your red blood cell count during treatment
  • If your anemia is severe, your healthcare provider may tell you to stop taking INCIVEK. If this happens, do not start taking it again

Birth defects or death of an unborn baby

  • Birth defects or death of an unborn baby. INCIVEK combined with peginterferon alfa and ribavirin may cause birth defects or death of your unborn baby. If you or your sexual partner is pregnant or plan to become pregnant, do not take these medicines. You or your partner should not become pregnant while taking INCIVEK with peginterferon alfa and ribavirin and for 6 months after treatment is over
  • If you are a female who can become pregnant, or if you are a female whose male partner takes these medicines:
    • You must have a negative pregnancy test before starting treatment, every month during treatment, and for 6 months after your treatment ends
    • You must use 2 effective methods of birth control during treatment and for 6 months after all treatment has ended. These 2 forms of birth control should not contain hormones, as these may not work during treatment with INCIVEK. Talk to your healthcare provider about the forms of birth control you should use during this time
    • Two weeks after stopping INCIVEK, you can use a hormonal form of birth control as one of your two forms of birth control
    • If you or your partner becomes pregnant during treatment or within 6 months after stopping these medicines, tell your healthcare provider right away. Contact the Ribavirin Pregnancy Registry right away by calling 1-800-593-2214. The Registry collects information about what happens to mothers and their babies if the mother takes ribavirin while pregnant

Click here for tips to help manage some of these serious side effects.

Common side effects of INCIVEK Triple Therapy

The most common side effects include itching, nausea, diarrhea, vomiting, anal or rectal problems (including hemorrhoids, discomfort or burning around or near the anus, itching around or near the anus), taste changes, and tiredness.

It is important to stay hydrated with fluids during INCIVEK Triple Therapy. Signs and symptoms of dehydration include increased thirst, dry mouth, decreased urine frequency or volume, and dark colored urine.

Tell your healthcare provider about any side effect that bothers you or doesn't go away.

These are not all the possible side effects of INCIVEK. For more information, ask your healthcare provider or pharmacist.

How can I prevent pregnancy while on treatment?

If you are a female who can become pregnant, or if you are a female whose male partner takes these medicines:

  • You must use 2 effective methods of birth control during treatment and for 6 months after all treatment has ended. These 2 forms of birth control should not contain hormones, as these may not work during treatment with INCIVEK. Talk to your healthcare provider about the forms of birth control you should use during this time

    These may include:

    • A male condom with spermicidal jelly OR a female condom with spermicidal jelly (a combination of a male condom and a female condom is not suitable)
    • A diaphragm with spermicidal jelly
    • A cervical cap with spermicidal jelly
    • An intrauterine device (IUD)
  • Two weeks after stopping INCIVEK, you can use a hormonal form of birth control as one of your two forms of birth control
  • You must have a negative pregnancy test before starting treatment, every month during treatment, and for 6 months after your treatment ends
Can INCIVEK be taken alone?

Do not take INCIVEK alone to treat chronic hepatitis C infection. It must be used with peginterferon alfa and ribavirin to treat chronic hepatitis C infection.

How should I take INCIVEK?
  • Take INCIVEK exactly as your healthcare provider tells you
  • Take 3 INCIVEK pills (a dose) 2 times a day. Each dose should be taken 10 to 14 hours apart, with food. Eat a meal or snack containing about 20 grams of fat within 30 minutes before you take each dose of INCIVEK (refer to the next question below to learn what kind of food you should eat when taking INCIVEK)
  • INCIVEK cannot be taken alone. You will also need a once-weekly peginterferon alfa injection and to take ribavirin as your healthcare provider has prescribed
  • Do not stop taking INCIVEK unless your healthcare provider tells you to. If you think there is a reason to stop taking INCIVEK, talk with your healthcare provider before doing so
  • If your healthcare provider tells you to stop taking INCIVEK, you should not start taking it again even if the reason for stopping goes away
  • If you take too much INCIVEK, call your healthcare provider or local Poison Control Center, or go to the nearest hospital emergency room right away
What kind of food should I eat when taking INCIVEK?

You need to take INCIVEK with food so that your body gets enough medicine to fight the virus. To help your body absorb INCIVEK:

  • Eat a meal or snack that has about 20 grams of fat
  • Be sure to eat that food within 30 minutes before taking each dose of INCIVEK

20 grams of fat may sound like a lot at first, but many common foods that you may already enjoy contain this much fat, such as:

  • A bagel with 4 tablespoons of cream cheese
  • 3 tablespoons of peanut butter
  • 1 cup of ice cream
  • 1/2 cup of trail mix

Of course, don't eat any foods that you are allergic to. Also, keep in mind any dietary restrictions you may have.

Learn more about foods you can eat with INCIVEK.

Why do I have to take INCIVEK 10 to 14 hours apart?

For INCIVEK Triple Therapy to work, you need to take it at the times your healthcare provider tells you to. This is because you need to have a steady amount of it in your body throughout your treatment.

What should I do if I forget to take INCIVEK?
  • If you miss a dose within 6 hours of when you usually take it, take your dose with food as soon as possible
  • If you miss a dose and it is more than 6 hours after the time you usually take it, skip that dose only and take your next dose at your normal time
How long will my INCIVEK Triple Therapy last?

Take your medicine for as long as your healthcare provider tells you to. Don't stop taking INCIVEK, or any of your medicines, without first talking to your healthcare provider. Generally, your treatment will be as follows:

  • For the first 12 weeks of therapy, you will take INCIVEK with peginterferon alfa and ribavirin
  • The INCIVEK part of your treatment is complete at week 12. You will continue taking peginterferon alfa and ribavirin alone for another 12 or 36 weeks, depending on your treatment history, liver health, and response
  • You will have lab tests to check how much of the virus is in your blood (viral load) throughout your treatment, including at weeks 4, 12, and 24. These lab tests will determine how INCIVEK Triple Therapy is working for you. Based on these results and your treatment history, your healthcare provider will either:
    • Continue your treatment if it is working and decide how long your treatment will be
    • Stop your treatment if it is not working
Will I need to have lab tests, and if so, how often?

Certain lab tests, along with your treatment history and liver health, help your healthcare provider understand how and if your body is responding to treatment and help them decide how long your treatment will be. Other lab tests help your healthcare provider see if you are having certain side effects.

Throughout treatment, your healthcare provider will check:

  • Your viral load. A viral load tells your healthcare provider how much of the hepatitis C virus is in your blood
  • If you have anemia (low red blood cell count)
  • If you have certain other side effects

Some of these tests should be before you start treatment and will be at least at weeks 2, 4, 8, and 12 during INCIVEK Triple Therapy. Your healthcare provider may do earlier and more frequent testing. If your body is not responding to treatment or you experience side effects that are severe at any point, your healthcare provider may stop your treatment.

Talk to your healthcare provider if you have any questions about your lab tests.

Can I infect another person with the hepatitis C virus
during treatment?

It is not known if treatment with INCIVEK Triple Therapy will prevent you from infecting another person with the hepatitis C virus while you’re on treatment or if you do not respond to treatment. Talk to your healthcare provider about ways to avoid infecting others.

How can I relieve itching without scratching?

If your skin feels itchy and you want to scratch it, instead try to:

  • Pat the itchy area with the flat of your hand
  • Pinch the itchy area with your fingertips (not too hard)
  • Put something cold on the itchy area (like ice cubes or frozen peas, wrapped in a towel or cloth)

Click here for more tips on how to keep your skin healthy during treatment, or call your healthcare provider.

How should I store INCIVEK?

INCIVEK does not need to be refrigerated. Store your INCIVEK pills at room temperature between 68°F to 77°F (20°C to 25°C). Keep INCIVEK and all medicines out of the reach of children.

Where can I find out about insurance coverage and paying
for INCIVEK?

Our reimbursement specialists are available to help you understand your insurance coverage, cost of therapy, and if you are eligible to receive financial assistance from Vertex. If you need help paying for INCIVEK, click here or call 1-855-VERTEXGPS (1-855-837-8394) to find out how we can help.

Do you offer any assistance if I have trouble getting my INCIVEK medication?

As part of Vertex GPS services, we may be able to assist eligible patients who either experience or will experience a delay receiving their INCIVEK medication from their pharmacy through our GPS Emergency Supply Program.

To access this service and learn more, please call Vertex GPS at
1-855-VERTEXGPS (1-855-837-8394).

SOME GOOD NEWS: CHRONIC HEPATITIS C
CAN BE CURED IN MANY PATIENTS

With INCIVEK Triple Therapy, there's a better
chance for a cure* than with peginterferon alfa
and ribavirin alone.

Find out more

Support every step of the way

Vertex provides product support services and
educational resources for patients taking INCIVEK
that can help every step of the way.

Learn More

Meet Real Fighters

Get to know some of the real fighters who took on
the challenge and were cured* of chronic hepatitis C.
Their insights may help you in your own fight.

Get introduced

It is important to note that not everyone who took part in a
clinical trial was cured. The people shown in this website
share their own experiences; yours may be different.

*Cure, or clearing the virus, means the hepatitis C virus is
not detectable in your blood 6 months after you finish all
treatment. This is also known as Sustained Virologic
Response (SVR).

What is INCIVEK?

INCIVEK® (telaprevir) is a prescription medicine used with the medicines peginterferon alfa and ribavirin to treat chronic (lasting a long time) hepatitis C genotype 1 infection in adults with stable liver problems, who have not been treated before or who have failed previous treatment.


It is not known if INCIVEK is safe and effective in children under 18 years of age.

Important Safety Information

Serious Side Effects

INCIVEK combination treatment may cause serious side effects, including:

  • Skin rash and serious skin reactions. Skin rashes are common with INCIVEK combination treatment. Sometimes these skin rashes and other skin reactions can become serious, require treatment in a hospital, and may lead to death.
    Call your healthcare provider right away if you develop any skin changes or itching during treatment with INCIVEK.
    Your healthcare provider will decide if your skin changes or any of the following symptoms may be a sign of a serious skin reaction: skin rash with or without itching, fever, swelling of your face, blisters or skin lesions, mouth sores or ulcers, or red or inflamed eyes, like “pink eye” (conjunctivitis). Your healthcare provider will decide if you need treatment for your skin rash or if you need to stop taking INCIVEK or any of your other medicines. Never stop taking INCIVEK combination treatment without talking with your healthcare provider first.
  • Low red blood cell count (anemia) that can be severe. Tell your healthcare provider if you have any of these symptoms of anemia: dizziness, shortness of breath, tiredness, or weakness.
    Your healthcare provider will do blood tests regularly to check your red blood cell count during treatment. If your anemia is severe, your healthcare provider may tell you to stop taking INCIVEK. If this happens, do not start taking it again.
  • Birth defects or death of an unborn baby. INCIVEK combined with peginterferon alfa and ribavirin may cause birth defects or death of your unborn baby. If you or your sexual partner is pregnant or plan to become pregnant, do not take these medicines. You or your partner should not become pregnant while taking INCIVEK with peginterferon alfa and ribavirin and for 6 months after treatment is over.
    If you are a female who can become pregnant, or if you are a female whose male partner takes these medicines:
    • You must have a negative pregnancy test before starting treatment, every month during treatment, and for 6 months after your treatment ends.
    • You must use 2 effective methods of birth control during treatment and for 6 months after all treatment has ended. These 2 forms of birth control should not contain hormones, as these may not work during treatment with INCIVEK. Talk to your healthcare provider about the forms of birth control you should use during this time.
      Two weeks after stopping INCIVEK, you can use a hormonal form of birth control as one of your two forms of birth control.
    • If you or your partner becomes pregnant during treatment or within 6 months after stopping these medicines, tell your healthcare provider right away. Contact the Ribavirin Pregnancy Registry right away by calling 1-800-593-2214. The Registry collects information about what happens to mothers and their babies if the mother takes ribavirin while pregnant.

Who should not take INCIVEK?

What should I tell my healthcare provider before taking INCIVEK?

Tell your healthcare provider if you:

  • have certain blood problems such as low red blood cell count (anemia)
  • have liver problems other than hepatitis C infection
  • have hepatitis B, HIV infection, or any problems with your immune system
  • have a history of gout or high uric acid levels in your blood
  • have had an organ transplant
  • plan to have surgery
  • have any other medical condition
  • are breastfeeding

How should I take INCIVEK?

Do not take INCIVEK alone to treat chronic hepatitis C infection. It must be used with peginterferon alfa and ribavirin to treat chronic hepatitis C infection.


Take INCIVEK exactly as your healthcare provider tells you. Do not stop taking INCIVEK unless your healthcare provider tells you to. If your healthcare provider tells you to stop, you should not start taking it again, even if the reason for stopping goes away. If you take too much INCIVEK, call your healthcare provider or local Poison Control Center, or go to the nearest emergency room right away.

Common Side Effects of INCIVEK Combination Treatment

The most common side effects include itching, nausea, diarrhea, vomiting, anal or rectal problems (including hemorrhoids, discomfort or burning around or near the anus, itching around or near the anus), taste changes, and tiredness. Tell your healthcare provider about any side effect that bothers you or doesn’t go away.


These are not all the possible side effects of INCIVEK. For more information, ask your healthcare provider or pharmacist. Please see full Prescribing Information for INCIVEK, including Boxed Warning, and read the Medication Guide. Please see full Prescribing Information and read the Medication Guides for peginterferon alfa and ribavirin. This site is intended for U.S. audiences only. All other audiences please click here.